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World J Radiol. 2015 Sep 28;7(9):236-52. doi: 10.4329/wjr.v7.i9.236.

Ankylosing spondylitis: A state of the art factual backbone.

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Mohammad Ghasemi-rad, Hosam Attaya, Division of Interventional Radiology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, United States.


Ankylosing spondylitis (AS) is a chronic inflammatory disease that affects 1% of the general population. As one of the most severe types of spondyloarthropathy, AS affects the spinal vertebrae and sacroiliac joints, causing debilitating pain and loss of mobility. The goal of this review is to provide an overview of AS, from the pathophysiological changes that occur as the disease progresses, to genetic factors that are involved with its onset. Considering the high prevalence in the population, and the debilitating life changes that occur as a result of the disease, a strong emphasis is placed on the diagnostic imaging methods that are used to detect this condition, as well as several treatment methods that could improve the health of individuals diagnosed with AS.


Ankylosing spondylitis; Computed tomography; Diagnosis; Magnetic resonance imaging; Treatment; Ultrasound

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