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J Agric Food Chem. 2015 Oct 21;63(41):9037-46. doi: 10.1021/acs.jafc.5b03836. Epub 2015 Oct 13.

Cassia tora Seed Extract and Its Active Compound Aurantio-obtusin Inhibit Allergic Responses in IgE-Mediated Mast Cells and Anaphylactic Models.

Author information

1
Natural Products Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute , Gangwon, Korea.

Abstract

Cassia tora seed is widely used due to its various biological properties including anticancer, antidiabetic, and anti-inflammatory effects. However, there has been no report of the effects of C. tora seed extract (CTE) on immunoglobulin E (IgE)-mediated allergic responses. In this research, we demonstrated the effects of CTE and its active compound aurantio-obtusin on IgE-sensitized allergic reactions in mast cells and passive cutaneous anaphylaxis (PCA). CTE and aurantio-obtusin suppressed degranulation, histamine production, and reactive oxygen species generation and inhibited the production and mRNA expression of tumor necrosis factor-α and interleukin-4. CTE and aurantio-obtusin also suppressed the prostaglandin E2 production and expression of cyclooxygenase 2. Furthermore, CTE and aurantio-obtusin suppressed IgE-mediated FcεRI signaling such as phosphorylation of Syk, protein kinase Cμ, phospholipase Cγ, and extracellular signal-regulated kinases. CTE and aurantio-obtusin blocked mast cell-dependent PCA in IgE-mediated mice. These results suggest that CTE and aurantio-obtusin are a beneficial treatment for allergy-related diseases.

KEYWORDS:

Cassia tora; IgE-mediated allergic diseases; RBL-2H3 mast cells; aurantio-obtusin

PMID:
26434611
DOI:
10.1021/acs.jafc.5b03836
[Indexed for MEDLINE]

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