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Food Chem. 2012 May 1;132(1):428-32. doi: 10.1016/j.foodchem.2011.11.016. Epub 2011 Nov 10.

Prebiotic effect of diosgenin, an immunoactive steroidal sapogenin of the Chinese yam.

Author information

1
Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan.
2
Institute of Nursing, Central Taiwan University of Science and Technology, No. 666, Buzi Rd., Beitun Dist., Taichung City 40601, Taiwan.
3
Animal Health Research Institute, Council of Agriculture, Executive Yuan, No. 376, Chung-Chung Rd., Tansui, New Taipei City 25158, Taiwan.
4
Department and Graduate Institute of Veterinary Medicine, School of Veterinary Medicine, National Taiwan University, No. 1, Sec. 4, Roosevelt Rd., Taipei 10617, Taiwan. Electronic address: tonyjan@ntu.edu.tw.

Abstract

This study investigated the effect of diosgenin, a yam-derived phytochemical, on the growth of enteric lactic acid bacteria (LAB). The in vivo effect of diosgenin on the density of intestinal flora was examined in a murine model of food allergy. Oral administration with diosgenin markedly restored the diminished density of faecal LAB associated with allergic reactions. The direct effect of diosgenin and several structure-related steroidal compounds on the growth of faecal anaerobes isolated from diosgenin-administered mice was also investigated. The presence of diosgenin significantly enhanced the growth of Lactobacillus murinus and Lactobacillus reuteri, but not enterococci. Structure-activity relationship analysis showed that the prebiotic activity of steroidal sapogenins might require structural elements of the C5-C6 double bond and intact E- and F-rings. Collectively, these results indicate that steroidal sapogenins may be a novel class of prebiotics to LAB.

KEYWORDS:

Chinese yam; Diosgenin; Lactobacillus; Prebiotic; Sapogenin

PMID:
26434311
DOI:
10.1016/j.foodchem.2011.11.016
[Indexed for MEDLINE]

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