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Food Chem. 2012 May 1;132(1):385-90. doi: 10.1016/j.foodchem.2011.11.005. Epub 2011 Nov 10.

Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits.

Author information

1
Department of Biochemistry, Shivaji University, Kolhapur, Maharashtra 416004, India.
2
Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra 416416, India.
3
Ayurveda Clinic, Kolhapur, Maharashtra 416008, India.
4
Department of Biochemistry, Shivaji University, Kolhapur, Maharashtra 416004, India. Electronic address: drauarvindekar@yahoo.co.in.

Abstract

Foeniculum vulgare fruits are routinely consumed for their carminative and mouth freshening effect. The plant was evaluated for aldose reductase inhibition and anti-diabetic action. Bioguided fractionation using silica gel column chromatography, HPLC, and GC-MS analysis revealed trans-anethole as the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value of 3.8μg/ml. Prolonged treatment with the pet ether fraction of the F. vulgare distillate demonstrated improvement in blood glucose, lipid profile, glycated haemoglobin and other parameters in streptozotocin-induced diabetic rats. Trans-anethole could effectively show anti-cataract activity through the increase in soluble lens protein, reduced glutathione, catalase and SOD activity on in vitro incubation of the eye lens with 55mM glucose. Trans-anethole demonstrated noncompetitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot.

KEYWORDS:

Aldose reductase inhibitor; Anti-cataract; Antidiabetic; Foeniculum vulgare; Trans-anethole

PMID:
26434305
DOI:
10.1016/j.foodchem.2011.11.005
[Indexed for MEDLINE]

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