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Food Chem. 2012 May 1;132(1):385-90. doi: 10.1016/j.foodchem.2011.11.005. Epub 2011 Nov 10.

Inhibition of aldose reductase and anti-cataract action of trans-anethole isolated from Foeniculum vulgare Mill. fruits.

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Department of Biochemistry, Shivaji University, Kolhapur, Maharashtra 416004, India.
Appasaheb Birnale College of Pharmacy, Sangli, Maharashtra 416416, India.
Ayurveda Clinic, Kolhapur, Maharashtra 416008, India.
Department of Biochemistry, Shivaji University, Kolhapur, Maharashtra 416004, India. Electronic address:


Foeniculum vulgare fruits are routinely consumed for their carminative and mouth freshening effect. The plant was evaluated for aldose reductase inhibition and anti-diabetic action. Bioguided fractionation using silica gel column chromatography, HPLC, and GC-MS analysis revealed trans-anethole as the bioactive constituent possessing potent aldose reductase inhibitory action, with an IC50 value of 3.8μg/ml. Prolonged treatment with the pet ether fraction of the F. vulgare distillate demonstrated improvement in blood glucose, lipid profile, glycated haemoglobin and other parameters in streptozotocin-induced diabetic rats. Trans-anethole could effectively show anti-cataract activity through the increase in soluble lens protein, reduced glutathione, catalase and SOD activity on in vitro incubation of the eye lens with 55mM glucose. Trans-anethole demonstrated noncompetitive to mixed type of inhibition of lens aldose reductase using Lineweaver Burk plot.


Aldose reductase inhibitor; Anti-cataract; Antidiabetic; Foeniculum vulgare; Trans-anethole

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