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Trends Biochem Sci. 2015 Nov;40(11):624-627. doi: 10.1016/j.tibs.2015.09.004. Epub 2015 Oct 1.

Spotlighted Brains: Optogenetic Activation and Silencing of Neurons.

Author information

1
Department of Cellular and Developmental Biology of Plants, University of Bielefeld, Universitätsstrasse 25, D-33615 Bielefeld, Germany. Electronic address: kianian@uni-bielefeld.de.
2
Department of Cellular and Developmental Biology of Plants, University of Bielefeld, Universitätsstrasse 25, D-33615 Bielefeld, Germany.

Abstract

Optogenetics is revolutionizing cell biology and neuroscience research by allowing precise biochemical control of neuronal activity through light-activated channels. Light-induced ion transporters have been used extensively for cellular activation, and now light-gated inhibitory channels have been discovered. These represent a key new tool to elucidate the molecular mechanisms underlying neurological and neuropsychiatric disorders.

KEYWORDS:

Channelrhodopsins; Optical neuronal silencers; Optogenetics; Rhodopsin-like photoreceptors; Synthetic biology

PMID:
26433473
DOI:
10.1016/j.tibs.2015.09.004
[Indexed for MEDLINE]

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