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J Ind Microbiol Biotechnol. 2016 Mar;43(2-3):233-48. doi: 10.1007/s10295-015-1686-6. Epub 2015 Oct 3.

David and Goliath: chemical perturbation of eukaryotes by bacteria.

Author information

1
Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada.
2
Department of Biochemistry, University of Toronto, 1 King's College Circle, Toronto, ON, M5S 1A8, Canada. Justin.nodwell@utoronto.ca.

Abstract

Environmental microbes produce biologically active small molecules that have been mined extensively as antibiotics and a smaller number of drugs that act on eukaryotic cells. It is known that there are additional bioactives to be discovered from this source. While the discovery of new antibiotics is challenged by the frequent discovery of known compounds, we contend that the eukaryote-active compounds may be less saturated. Indeed, despite there being far fewer eukaryotic-active natural products these molecules interact with a far richer diversity of molecular and cellular targets.

KEYWORDS:

Actinomycetes; Eukaryotes; Target diversity

PMID:
26433385
PMCID:
PMC4752587
DOI:
10.1007/s10295-015-1686-6
[Indexed for MEDLINE]
Free PMC Article

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