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J Am Soc Nephrol. 2016 May;27(5):1566-74. doi: 10.1681/ASN.2015030312. Epub 2015 Oct 2.

The Choice of Hemodialysis Membrane Affects Bisphenol A Levels in Blood.

Author information

1
Renal, Vascular and Diabetes Laboratory, and.
2
Renal, Vascular and Diabetes Laboratory, and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; smas@fjd.es.
3
Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain;
4
Division of Nephrology, Hospital Universitario de Burgos, Burgos, Spain;
5
Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Red Española de Investigación Renal, Madrid, Spain;
6
Renal, Vascular and Diabetes Laboratory, and Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Red Española de Investigación Renal, Madrid, Spain; Department of Medicine, UAM Medical School, Madrid, Spain; and Fundación Renal Íñigo Álvarez de Toledo/Instituto Reina Sofía de Investigación en Nefrología, Madrid, Spain.
7
Renal, Vascular and Diabetes Laboratory, and Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Department of Medicine, UAM Medical School, Madrid, Spain; and Fundación Renal Íñigo Álvarez de Toledo/Instituto Reina Sofía de Investigación en Nefrología, Madrid, Spain.
8
Spanish Biomedical Research Centre in Diabetes and Associated Metabolic Disorders (CIBERDEM), Madrid, Spain; Division of Nephrology and Hypertension, IIS-Fundación Jimenez Diaz Universidad Autónoma de Madrid (UAM), Madrid, Spain; Red Española de Investigación Renal, Madrid, Spain; Department of Medicine, UAM Medical School, Madrid, Spain; and Fundación Renal Íñigo Álvarez de Toledo/Instituto Reina Sofía de Investigación en Nefrología, Madrid, Spain.

Abstract

Bisphenol A (BPA), a component of some dialysis membranes, accumulates in CKD. Observational studies have linked BPA exposure to kidney and cardiovascular injury in humans, and animal studies have described a causative link. Normal kidneys rapidly excrete BPA, but insufficient excretion may sensitize patients with CKD to adverse the effects of BPA. Using a crossover design, we studied the effect of dialysis with BPA-containing polysulfone or BPA-free polynephron dialyzers on BPA levels in 69 prevalent patients on hemodialysis: 28 patients started on polysulfone dialyzers and were switched to polynephron dialyzers; 41 patients started on polynephron dialyzers and were switched to polysulfone dialyzers. Results were grouped for analysis. Mean BPA levels increased after one hemodialysis session with polysulfone dialyzers but not with polynephron dialyzers. Chronic (3-month) use of polysulfone dialyzers did not significantly increase predialysis serum BPA levels, although a trend toward increase was detected (from 48.8±6.8 to 69.1±10.1 ng/ml). Chronic use of polynephron dialyzers reduced predialysis serum BPA (from 70.6±8.4 to 47.1±7.5 ng/ml, P<0.05). Intracellular BPA in PBMCs increased after chronic hemodialysis with polysulfone dialyzers (from 0.039±0.002 to 0.043±0.001 ng/10(6) cells, P<0.01), but decreased with polynephron dialyzers (from 0.045±0.001 to 0.036±0.001 ng/10(6) cells, P<0.01). Furthermore, chronic hemodialysis with polysulfone dialyzers increased oxidative stress in PBMCs and inflammatory marker concentrations in circulation. In vitro, polysulfone membranes released significantly more BPA into the culture medium and induced more cytokine production in cultured PBMCs than did polynephron membranes. In conclusion, dialyzer BPA content may contribute to BPA burden in patients on hemodialysis.

KEYWORDS:

ESRD; hemodialysis; oxidative stress

PMID:
26432902
PMCID:
PMC4849825
DOI:
10.1681/ASN.2015030312
[Indexed for MEDLINE]
Free PMC Article

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