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Curr Opin Immunol. 2015 Dec;37:11-20. doi: 10.1016/j.coi.2015.09.002. Epub 2015 Sep 29.

Targeting Treg signaling for the treatment of autoimmune diseases.

Author information

1
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
2
UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: jeff.bluestone@ucsf.edu.
3
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA; UCSF Diabetes Center, University of California, San Francisco, San Francisco, CA 94143, USA. Electronic address: qizhi.tang@ucsf.edu.

Abstract

Regulatory T (Treg) cells are crucial players in the prevention of autoimmunity. Treg lineage commitment and functional stability are influenced by selected extracellular signals from the local environment, shaped by distinctive intracellular signaling network, and secured by their unique epigenetic profile. Recent advances in our understanding of the complex processes of Treg lineage differentiation, maintenance, and function has paved the way for developing strategies to manipulate these important cells for therapeutic benefit in many diseases. In this review, we will summarize recent advances in our understanding of Treg biology as well as Treg-targeted therapies in the context of autoimmune disease.

PMID:
26432763
PMCID:
PMC4679451
DOI:
10.1016/j.coi.2015.09.002
[Indexed for MEDLINE]
Free PMC Article

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