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FEBS J. 2015 Dec;282(24):4672-8. doi: 10.1111/febs.13540. Epub 2015 Oct 16.

p62/SQSTM1 functions as a signaling hub and an autophagy adaptor.

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Department of Biochemistry, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan.


p62/SQSTM1 is a stress-inducible cellular protein that is conserved among metazoans but not in plants and fungi. p62/SQSTM1 has multiple domains that mediate its interactions with various binding partners and it serves as a signaling hub for diverse cellular events such as amino acid sensing and the oxidative stress response. In addition, p62/SQSTM1 functions as a selective autophagy receptor for degradation of ubiqutinated substrates. In the present review, we describe the current knowledge about p62 with regard to mammalian target of rapamycin complex 1 activation, the Keap1-Nrf2 pathway and selective autophagy.


Keap1-Nrf2 system; mTORC1; p62/Sqstm1; selective autophagy; ubiquitination

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