Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry

Nicholas J Brandon

doi:10.1016/j.cellsig.2015.09.019

Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry

Cell Signal. 2016 Jul;28(7):749-52. doi: 10.1016/j.cellsig.2015.09.019. Epub 2015 Sep 30.

Author

Nicholas J Brandon¹

Affiliation

¹ Astrazeneca Neuroscience iMED, 141, Portland St, Cambridge, MA 02139 USA. Electronic address: nick.brandon@azneuro.com.

PMID: 26432168
DOI: 10.1016/j.cellsig.2015.09.019

Abstract

Nearly 10years ago the laboratory of Miles Houslay was part of a collaboration which identified and characterized the interaction between Disrupted in Schizophrenia 1 and phosphodiesterase type 4. This work has had significant impact on our thinking of psychiatric illness causation and the potential for therapeutics.

Keywords: DISC1; PDE4; Schizophrenia.

Publication types

Review

MeSH terms

Cyclic AMP / metabolism
Cyclic Nucleotide Phosphodiesterases, Type 4 / metabolism*
Humans
Models, Biological
Nerve Tissue Proteins / metabolism*
Protein Binding
Psychiatry*

Substances

Nerve Tissue Proteins
Cyclic AMP
Cyclic Nucleotide Phosphodiesterases, Type 4