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Cell Signal. 2016 Jul;28(7):749-52. doi: 10.1016/j.cellsig.2015.09.019. Epub 2015 Sep 30.

Uncovering the function of Disrupted in Schizophrenia 1 through interactions with the cAMP phosphodiesterase PDE4: Contributions of the Houslay lab to molecular psychiatry.

Author information

1
Astrazeneca Neuroscience iMED, 141, Portland St, Cambridge, MA 02139 USA. Electronic address: nick.brandon@azneuro.com.

Abstract

Nearly 10years ago the laboratory of Miles Houslay was part of a collaboration which identified and characterized the interaction between Disrupted in Schizophrenia 1 and phosphodiesterase type 4. This work has had significant impact on our thinking of psychiatric illness causation and the potential for therapeutics.

KEYWORDS:

DISC1; PDE4; Schizophrenia

PMID:
26432168
DOI:
10.1016/j.cellsig.2015.09.019
[Indexed for MEDLINE]

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