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Trends Immunol. 2015 Oct;36(10):637-650. doi: 10.1016/j.it.2015.08.002.

Immune Surveillance of the CNS following Infection and Injury.

Author information

1
Viral Immunology and Intravital Imaging Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
2
Viral Immunology and Intravital Imaging Section, National Institutes of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. Electronic address: mcgavernd@mail.nih.gov.

Abstract

The central nervous system (CNS) contains a sophisticated neural network that must be constantly surveyed in order to detect and mitigate a diverse array of challenges. The innate and adaptive immune systems actively participate in this surveillance, which is critical for the maintenance of CNS homeostasis and can facilitate the resolution of infections, degeneration, and tissue damage. Infections and sterile injuries represent two common challenges imposed on the CNS that require a prompt immune response. While the inducers of these two challenges differ in origin, the resultant responses orchestrated by the CNS share some overlapping features. Here, we review how the CNS immunologically discriminates between pathogens and sterile injuries, mobilizes an immune reaction, and, ultimately, regulates local and peripherally-derived immune cells to provide a supportive milieu for tissue repair.

PMID:
26431941
PMCID:
PMC4592776
DOI:
10.1016/j.it.2015.08.002
[Indexed for MEDLINE]
Free PMC Article

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