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Folia Med (Plovdiv). 2015 Jan-Mar;57(1):56-64. doi: 10.1515/folmed-2015-0020.

Economic Burden And Health-Related Quality Of Life Of Patients With Cystic Fibrosis In Bulgaria.

Author information

1
Department of Social Medicine and Public Health, Faculty of Public Health, Medical University, Plovdiv, Bulgaria
2
Institute for Rare Diseases, Plovdiv, Bulgaria
3
University of Castilla-La Mancha, Talavera de la Reina, Toledo, Spain
4
Red de Investigación en Servicios Sanitarios en Enfermedades Crónicas (REDISSEC), Spain
5
Fundación Canaria de Investigación Sanitaria (FUNCANIS), Spain
6
University of Castilla-La Mancha, Toledo, Spain
7
Evaluation and Planning Service at Canary Islands Health Service (SESCS), Santa Cruz de Tenerife, Spain

Abstract

OBJECTIVE:

The aim of this study was to determine the economic burden from a societal perspective and health-related quality of life (HRQOL) of patients with cystic fibrosis (CF) in Bulgaria.

MATERIALS AND METHODS:

We conducted a cross-sectional study of 33 patients with CF and 17 caregivers from Bulgaria. Data on socio-demographic characteristics, health resource utilisation, informal care, labor productivity losses and HRQOL were collected from questionnaires completed by patients or their caregivers. HRQOL was evaluated with the EuroQol 5-domain (EQ-5D-3L) questionnaire.

RESULTS:

Median annual costs of CF in Bulgaria were € 24 152 per patient in 2012 as a reference year. Median annual costs for children were found to be significantly higher than those for adults - € 31 945 vs. € 15 714 (p = 0.012). This outcome came from statistically significant differences in costs for main informal carer (p < 0.001) and costs for other informal carers (p = 0.022). As a single cost item, drugs had the biggest monetary impact. Median annual drug costs were € 13 059. Bulgarian CF patients showed low HRQOL results - 50 median VAS score and 0.592 median health utilities. A quarter of patients even rated their health state as worse than death.

CONCLUSION:

CF patients from Eastern Europe remain a vulnerable population with risk factors for worse health outcomes. Our study provided a state-of-the art analysis that facilitates the elaboration, adoption and application of targeted public health policies to tackle CF-related problems at national and European level.

PMID:
26431096
DOI:
10.1515/folmed-2015-0020
[Indexed for MEDLINE]

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