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Am J Clin Nutr. 2015 Oct;102(4):975-6. doi: 10.3945/ajcn.115.117283.

Is this the end of (-)-epicatechin, or not? New study highlights the complex challenges associated with research into the cardiovascular health benefits of bioactive food constituents.

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From Mars Inc., McLean, VA (HS); Department of Nutrition and Department of Internal Medicine, University of California, Davis, Davis, CA (CLK); Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, MA (HDS and JEM); Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA (HDS and JEM); and Department of Nutrition and Food Science, Texas A&M University, College Station, TX, Emeritus (JRL, e-mail:

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