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Ann Biomed Eng. 2016 May;44(5):1502-14. doi: 10.1007/s10439-015-1461-x. Epub 2015 Oct 1.

Association of Intraluminal Thrombus, Hemodynamic Forces, and Abdominal Aortic Aneurysm Expansion Using Longitudinal CT Images.

Author information

1
Department of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
2
Department of Statistics and Probability, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
3
Department of Electrical and Computer Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA.
4
Department of Radiology, 101 Daehangno, Jongno-gu, Seoul, Korea.
5
Department of Mechanical Engineering, Michigan State University, 2555 Engineering Building, East Lansing, MI, 48824, USA. sbaek@egr.msu.edu.

Abstract

While hemodynamic forces and intraluminal thrombus (ILT) are believed to play important roles on abdominal aortic aneurysm (AAA), it has been suggested that hemodynamic forces and ILT also interact with each other, making it a complex problem. There is, however, a pressing need to understand relationships among three factors: hemodynamics, ILT accumulation, and AAA expansion for AAA prognosis. Hence this study used longitudinal computer tomography scans from 14 patients and analyzed the relationship between them. Hemodynamic forces, represented by wall shear stress (WSS), were obtained from computational fluid dynamics; ILT accumulation was described by ILT thickness distribution changes between consecutives scans, and ILT accumulation and AAA expansion rates were estimated from changes in ILT and AAA volume. Results showed that, while low WSS was observed at regions where ILT accumulated, the rate at which ILT accumulated occurred at the same rate as the aneurysm expansion. Comparison between AAAs with and without thrombus showed that aneurysm with ILT recorded lower values of WSS and higher values of AAA expansion than those without thrombus. Findings suggest that low WSS may promote ILT accumulation and submit the idea that by increasing WSS levels ILT accumulation may be prevented.

KEYWORDS:

CFD; Thrombosis; Vascular growth and remodeling

PMID:
26429788
PMCID:
PMC4826625
DOI:
10.1007/s10439-015-1461-x
[Indexed for MEDLINE]
Free PMC Article

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