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Monoamine Oxidase Inhibitory Action of Chalcones: A Mini Review.

Author information

1
Division of Drug Design and Medicinal Chemistry Research Lab, Department of Pharmaceutical Chemistry, Grace, College of Pharmacy, Palakkad -678004, Kerala, India. bijovilaventgu@gmail.com.

Abstract

INTRODUCTION:

Chalcones are one of the major classes of naturally occurring compounds and have a vast significance in medicinal chemistry, presenting with a wide scope of pharmacological actions.

DISCUSSION:

The present review focused our attention onto the monoamine oxidase inhibitory activity of natural and synthetic chalcones. The review also emphasises the structure-activity relationship studies and molecular recognition of chalcones towards MAO-A and B inhibition.

CONCLUSION:

Many of the studies clearly revealed that most of the chalcones showed selective, reversible and potent MAO-B inhibition compared to MAO-A. Recent studies also showed that heteroaryl-based chalcones are potent MAO-A inhibitors.

PMID:
26429556
[Indexed for MEDLINE]

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