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J Microbiol Biotechnol. 2015 Dec 28;25(12):2160-8. doi: 10.4014/jmb.1509.09021.

Clinical Evidence of Effects of Lactobacillus plantarum HY7714 on Skin Aging: A Randomized, Double Blind, Placebo-Controlled Study.

Author information

1
Korea Yakult Co., Ltd., Yongin 446-901, Republic of Korea.
2
Graduate School of International Agricultural Technology, Institute of Green Bio Science & Technology, Seoul National University, Pyeongchang 232-916, Republic of Korea.
3
Dermapro Skin Research Center, DERMAPRO Ltd., Seoul 137-843, Republic of Korea.

Abstract

The beneficial effects of probiotics are now widely reported, although there are only a few studies on their anti-aging effects. We have found that Lactobacillus plantarum HY7714 (HY7714) improves skin hydration and has anti-photoaging effects, and in the present study, we have further evaluated the anti-aging effect of HY7714 via a randomized, double blind, placebo-controlled clinical trial. The trial included 110 volunteers aged 41 and 59 years who have dry skin and wrinkles. Participants took 1 × 10(10) CFU/day of HY7714 (probiotic group) or a placebo (placebo group) for 12 weeks. Skin hydration, wrinkles, skin gloss, and skin elasticity were measured every 4 weeks during the study period. There were significant increases in the skin water content in the face (p < 0.01) and hands (p < 0.05) at week 12 in the probiotic group. Transepidermal water loss decreased significantly in both groups at weeks 4, 8, and 12 (p < 0.001 compared with baseline), and was suppressed to a greater extent in the face and forearm in the probiotic group at week 12. Volunteers in the probiotic group had a significant reduction in wrinkle depth at week 12, and skin gloss was also significantly improved by week 12. Finally, skin elasticity in the probiotic group improved by 13.17% (p < 0.05 vs. controls) after 4 weeks and by 21.73% (p < 0.01 vs. controls) after 12 weeks. These findings are preliminary confirmation of the anti-aging benefit to the skin of L. plantarum HY7714 as a nutricosmetic agent.

KEYWORDS:

Anti-wrinkle; Lactobacillus plantarum; Skin elasticity; Skin gloss; Skin hydration

PMID:
26428734
DOI:
10.4014/jmb.1509.09021
[Indexed for MEDLINE]
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