Format

Send to

Choose Destination
Am J Cardiol. 2015 Nov 15;116(10):1566-73. doi: 10.1016/j.amjcard.2015.08.021. Epub 2015 Aug 31.

Comparison of aortic root anatomy and calcification distribution between Asian and Caucasian patients who underwent transcatheter aortic valve implantation.

Author information

1
Department of Cardiology, University of Ulsan, Asan Medical Center, Seoul, Korea.
2
Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy; Department of Cardiology, University of Tokai School of Medicine, Isehara, Japan.
3
Department of Cardiology, Saiseikai Yokohama City Eastern Hospital, Kanagawa, Japan.
4
Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy.
5
Department of Cardiology, National Taiwan University Hospital, Taipei, Taiwan.
6
Department of Radiology, University of Ulsan, Asan Medical Center, Seoul, Korea.
7
Department of Cardiology, Ferrarotto Hospital, University of Catania, Catania, Italy; Excellence Through Newest Advances Foundation, Catania, Italy.
8
Department of Cardiology, University of Ulsan, Asan Medical Center, Seoul, Korea. Electronic address: sjpark@amc.seoul.kr.

Abstract

The current transcatheter aortic valve implantation (TAVI) devices have been designed to fit Caucasian and Latin American aortic root anatomies. We evaluated the racial differences in aortic root anatomy and calcium distribution in patients with aortic stenosis who underwent TAVI. We conducted a multicenter study of 4 centers in Asia and Europe, which includes consecutive patients who underwent TAVI with preprocedural multidetector computed tomography. Quantitative assessment of aortic root dimensions, calcium volume for leaflet, and left ventricular outflow tract were retrospectively performed in a centralized core laboratory. A total of 308 patients (Asian group, n = 202; Caucasian group, n = 106) were analyzed. Compared to Caucasian group, Asian group had smaller annulus area (406.3 ± 69.8 vs 430.0 ± 76.8 mm(2); p = 0.007) and left coronary cusp diameter (30.2 ± 3.2 vs 31.1 ± 3.4 mm; p = 0.02) and lower height of left coronary artery ostia (12.0 ± 2.5 vs 13.4 ± 3.4 mm; p <0.001). Of baseline anatomic characteristics, body height showed the highest correlation with annulus area (Pearson correlation r = 0.64; p <0.001). Co-existence of lower height of left coronary artery ostia (<12 mm) and small diameter of left coronary cusp (<30 mm) were more frequent in Asian group compared with Caucasian group (35.6% vs 20.8%; p = 0.02). In contrast, there were no differences in calcium volumes of leaflet (367.2 ± 322.5 vs 359.1 ± 325.7 mm(3); p = 0.84) and left ventricular outflow tract (8.9 ± 23.4 vs 10.1 ± 23.8 mm(3); p = 0.66) between 2 groups. In conclusion, judicious consideration will be required to perform TAVI for short patients with lower height of left coronary artery ostia and small sinus of Valsalva.

PMID:
26428022
DOI:
10.1016/j.amjcard.2015.08.021
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center