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Hear Res. 2016 Feb;332:217-222. doi: 10.1016/j.heares.2015.09.013. Epub 2015 Sep 30.

Audiograms, gap detection thresholds, and frequency difference limens in cannabinoid receptor 1 knockout mice.

Author information

1
Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, USA. Electronic address: ktoal@buffalo.edu.
2
Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, USA. Electronic address: radziwon@buffalo.edu.
3
Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, USA. Electronic address: davidhol@buffalo.edu.
4
Department of Biological Sciences, University at Buffalo SUNY, Buffalo, NY 14260, USA. Electronic address: mx@buffalo.edu.
5
Department of Psychology, University at Buffalo SUNY, Buffalo, NY 14260, USA. Electronic address: mdent@buffalo.edu.

Abstract

The cannabinoid receptor 1 (CB1R) is found at several stages in the auditory pathway, but its role in hearing is unknown. Hearing abilities were measured in CB1R knockout mice and compared to those of wild-type mice. Operant conditioning and the psychophysical Method of Constant Stimuli were used to measure audiograms, gap detection thresholds, and frequency difference limens in trained mice using the same methods and stimuli as in previous experiments. CB1R knockout mice showed deficits at frequencies above 8 kHz in their audiograms relative to wild-type mice. CB1R knockouts showed enhancements for detecting gaps in low-pass noisebursts relative to wild-type mice, but were similar for other noise conditions. Finally, the two groups of mice did not differ in their frequency discrimination abilities as measured by the frequency difference limens task. These experiments suggest that the CB1R is involved in auditory processing and lay the groundwork for future physiological experiments.

KEYWORDS:

Audiogram; CB1R KO; CBA/CaJ; Difference limens; Gap detection; Mouse

PMID:
26427583
PMCID:
PMC4769947
DOI:
10.1016/j.heares.2015.09.013
[Indexed for MEDLINE]
Free PMC Article

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