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Adv Exp Med Biol. 2016;854:431-6. doi: 10.1007/978-3-319-17121-0_57.

Tauroursodeoxycholic Acid Protects Retinal Function and Structure in rd1 Mice.

Author information

1
Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. eric.lawson90@gmail.com.
2
Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. eric.lawson90@gmail.com.
3
Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. shagun88@gmail.com.
4
Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. shagun88@gmail.com.
5
Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. moonkwon.han@gmail.com.
6
Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. mhaung@emory.edu.
7
Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. mhaung@emory.edu.
8
Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. vciavat@emory.edu.
9
Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. vciavat@emory.edu.
10
Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. jboatri@emory.edu.
11
Department of Ophthalmology, Emory University School of Medicine, 30322, Atlanta, GA, USA. mpardue@emory.edu.
12
Rehab R&D Center, Research Service (151Oph), Atlanta VA Medical Center, 1670 Clairmont Rd., 30033, Decatur, GA, USA. mpardue@emory.edu.

Abstract

We explored the potential protective effects of tauroursodeoxycholic acid (TUDCA) on cone photoreceptor survival in a model of rapid retinal degeneration, the ß-Pde6 (rd1) (rd1) mouse model. We injected two strains of rd1 mice (B6.C3-Pde6b (rd1) Hps4(le)/J and C57BL/6J-Pde6b (rd1-2)/J mice) daily from postnatal day (P) 6 to P21 with TUDCA or vehicle. At P21, retinal function was evaluated with light-adapted electroretinography (ERG) and retinal structure was observed with plastic or frozen sections. TUDCA treatment partially preserved function and structure in B6.C3-Pde6b (rd1) Hps4(le)/J mice but only partially preserved structure in C57BL/6J-Pde6b (rd1-2)/J mice. Our results suggest a possible intervention for patients undergoing rapid retinal degeneration.

KEYWORDS:

Bile acids; Retinal degeneration; Retinitis pigmentosa; TUDCA; Tauroursodeoxycholic acid; rd1 mice

PMID:
26427442
DOI:
10.1007/978-3-319-17121-0_57
[Indexed for MEDLINE]

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