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Environ Sci Pollut Res Int. 2016 Feb;23(3):2454-66. doi: 10.1007/s11356-015-5314-9. Epub 2015 Oct 1.

Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats.

Author information

1
Department of Forensic Medicine and Toxicology, Zagazig University, Zagazig, 44111, Egypt. dr.mayadarf@gmail.com.
2
Department of Physiology, Zagazig University, Zagazig, 44111, Egypt.
3
Department of Biochemistry, Faculty of Veterinary Medicine, Zagazig University, Zagazig, 44111, Egypt.
4
Department of Forensic Medicine and clinical Toxicology, Faculty of Medicine, Zagazig University, Zagazig, 44111, Egypt.

Abstract

The present study was conducted to evaluate the ameliorative efficacy of Spirulina platensis (SP) on reproductive dysfunctions induced by cadmium chloride (CdCl2) in male rats. Rats (n = 40) were divided into five groups (eight rats/each). Group 1: served as control without any treatment. Group 2: Rats were administered SP (150 mg/kg body weight (BW)) in drinking water for 10 days. Group 3: Rats were subcutaneously injected with CdCl2 (2 mg/kg BW) daily for 10 days. Group 4: Rats were co-treated with both CdCl2 (2 mg/kg BW) and SP (150 mg/kg BW) daily for 10 days (SP prophylactic group). Group 5: Rats received CdCl2 for 10 days followed by administration of SP alone in drinking water daily for another 30 days with the same mentioned routes and doses (SP treatment group). From our findings, the administration of SP alone or co-administration with Cd significantly attenuated the harmful effects of Cd, suggesting its beneficial role in improving spermatogenesis and steroidogenesis after Cd exposure.

KEYWORDS:

Cadmium; Rat; Spermatogenesis; Spirulina platensis; Steroidogenesis

PMID:
26423278
DOI:
10.1007/s11356-015-5314-9
[Indexed for MEDLINE]

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