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Nat Rev Cancer. 2015 Aug;15(8):451-2. doi: 10.1038/nrc3972.

Patient-derived orthotopic xenografts: better mimic of metastasis than subcutaneous xenografts.

Abstract

The majority of human solid tumours do not metastasize when grown subcutaneously in immunocompromised mice; this includes patient-derived xenograft (PDX) models. However, orthotopic implantation of intact tumour tissue can lead to metastasis that mimics that seen in patients. These patient-derived orthotopic xenograft (PDOX) models have a long history and might better recapitulate human tumours than PDX models.

PMID:
26422835
DOI:
10.1038/nrc3972
[Indexed for MEDLINE]

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