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DNA Repair (Amst). 2015 Dec;36:19-27. doi: 10.1016/j.dnarep.2015.09.004. Epub 2015 Sep 9.

XPC: Going where no DNA damage sensor has gone before.

Author information

1
Department of Biochemistry and Molecular Biology, University of Miami Miller, School of Medicine Miami, FL 33136, United States.
2
Department of Biochemistry and Molecular Biology, University of Miami Miller, School of Medicine Miami, FL 33136, United States. Electronic address: fgong@med.miami.edu.

Abstract

XPC has long been considered instrumental in DNA damage recognition during global genome nucleotide excision repair (GG-NER). While this recognition is crucial for organismal health and survival, as XPC's recognition of lesions stimulates global genomic repair, more recent lines of research have uncovered many new non-canonical pathways in which XPC plays a role, such as base excision repair (BER), chromatin remodeling, cell signaling, proteolytic degradation, and cellular viability. Since the first discovery of its yeast homolog, Rad4, the involvement of XPC in cellular regulation has expanded considerably. Indeed, our understanding appears to barely scratch the surface of the incredible potential influence of XPC on maintaining proper cellular function. Here, we first review the canonical role of XPC in lesion recognition and then explore the new world of XPC function.

KEYWORDS:

BER; DNA repair; GG-NER; Nucleotide excision repair; Rad4; XPC

PMID:
26422135
PMCID:
PMC4872709
DOI:
10.1016/j.dnarep.2015.09.004
[Indexed for MEDLINE]
Free PMC Article

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