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JAMA Psychiatry. 2015 Nov;72(11):1110-8. doi: 10.1001/jamapsychiatry.2015.1559.

Effect of a Cognitive-Behavioral Prevention Program on Depression 6 Years After Implementation Among At-Risk Adolescents: A Randomized Clinical Trial.

Author information

1
Department of Psychiatry, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania2Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
2
Department of Psychology and Human Development, Vanderbilt University, Nashville, Tennessee.
3
Department of Psychology, Vanderbilt University, Nashville, Tennessee.
4
Joint Doctoral Program in Clinical Psychology, San Diego State University, San Diego, California, and University of California, San Diego, San Diego.
5
Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon.
6
Department of Psychiatry, Boston Children's Hospital, Boston, Massachusetts.
7
Wellesley Centers for Women, Wellesley College, Wellesley, Massachusetts.
8
Western Psychiatric Institute and Clinic, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania.
9
Department of Statistics, University of Pittsburgh, Pittsburgh, Pennsylvania.

Abstract

IMPORTANCE:

Adolescents whose parents have a history of depression are at risk for developing depression and functional impairment. The long-term effects of prevention programs on adolescent depression and functioning are not known.

OBJECTIVE:

To determine whether a cognitive-behavioral prevention (CBP) program reduced the incidence of depressive episodes, increased depression-free days, and improved developmental competence 6 years after implementation.

DESIGN, SETTING, AND PARTICIPANTS:

A 4-site randomized clinical trial compared the effect of CBP plus usual care vs usual care, through follow-up 75 months after the intervention (88% retention), with recruitment from August 2003 through February 2006 at a health maintenance organization, university medical centers, and a community mental health center. A total of 316 participants were 13 to 17 years of age at enrollment and had at least 1 parent with current or prior depressive episodes. Participants could not be in a current depressive episode but had to have subsyndromal depressive symptoms or a prior depressive episode currently in remission. Analysis was conducted between August 2014 and June 2015.

INTERVENTIONS:

The CBP program consisted of 8 weekly 90-minute group sessions followed by 6 monthly continuation sessions. Usual care consisted of any family-initiated mental health treatment.

MAIN OUTCOMES AND MEASURES:

The Depression Symptoms Rating scale was used to assess the primary outcome, new onsets of depressive episodes, and to calculate depression-free days. A modified Status Questionnaire assessed developmental competence (eg, academic or interpersonal) in young adulthood.

RESULTS:

Over the 75-month follow-up, youths assigned to CBP had a lower incidence of depression, adjusting for current parental depression at enrollment, site, and all interactions (hazard ratio, 0.71 [95% CI, 0.53-0.96]). The CBP program's overall significant effect was driven by a lower incidence of depressive episodes during the first 9 months after enrollment. The CBP program's benefit was seen in youths whose index parent was not depressed at enrollment, on depression incidence (hazard ratio, 0.54 [95% CI, 0.36-0.81]), depression-free days (d = 0.34, P = .01), and developmental competence (d = 0.36, P = .04); these effects on developmental competence were mediated via the CBP program's effect on depression-free days.

CONCLUSIONS AND RELEVANCE:

The effect of CBP on new onsets of depression was strongest early and was maintained throughout the follow-up period; developmental competence was positively affected 6 years later. The effectiveness of CBP may be enhanced by additional booster sessions and concomitant treatment of parental depression.

TRIAL REGISTRATION:

clinicaltrials.gov Identifier:NCT00073671.

PMID:
26421861
PMCID:
PMC4635056
DOI:
10.1001/jamapsychiatry.2015.1559
[Indexed for MEDLINE]
Free PMC Article

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