Format

Send to

Choose Destination
J Surg Oncol. 2015 Nov;112(6):592-6. doi: 10.1002/jso.24051. Epub 2015 Sep 30.

Correlation of minimal extrathyroidal extension with pathologic features of lymph node metastasis in patients with papillary thyroid carcinoma.

Author information

1
Department of Otolaryngology-Head and Neck Surgery, Kosin University College of Medicine, Busan, Korea.
2
Department of Otolaryngology-Head and Neck Surgery, Maryknoll Medical Center, Busan, Korea.
3
Department of Pathology, Kosin University College of Medicine, Busan, Korea.
4
Department of Otolaryngology-Head and Neck Surgery, Dong-A University College of Medicine, Busan, Korea.

Abstract

BACKGROUND:

The impact of minimal extrathyroidal extension (mETE) to the prognosis of patients with papillary thyroid carcinoma (PTC) is controversial. In this study, we investigated whether mETE is related to the aggressive biology of metastatic lymph node (LN) in patients with PTC.

METHODS:

A retrospective review of 369 patients who had biopsy-confirmed cervical LN metastasis after initial surgery for PTC was conducted. The correlations of mETE with the specific features of metastatic LNs such as the LN size, number, LN ratio, and presence of extranodal extension (ENE) were statistically analyzed.

RESULTS:

Size of the primary tumor (≥1 cm) had independent correlations to mETE (HR = 5.750). While mETE was related to number of metastatic LNs (≥5), LN ratio (≥0.31) and ENE in univariate analysis, only ENE (HR = 2.322) was independently correlated to mETE in our series. Along with mETE, size of primary tumor (≥1 cm) had significant impact on ENE (HR = 2.107).

CONCLUSION:

Minimal ETE particularly those with larger primary tumor (≥1 cm) may be still considered as a significant factor regarding the management of cervical LNs in patients with PTC.

KEYWORDS:

extracapsular spread; lymph nodes; neck dissection; papillary thyroid carcinoma

PMID:
26421594
DOI:
10.1002/jso.24051
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center