Format

Send to

Choose Destination
Biomed Res Int. 2015;2015:387653. doi: 10.1155/2015/387653. Epub 2015 Sep 1.

Evaluation of Liver Fibrosis Using Texture Analysis on Combined-Contrast-Enhanced Magnetic Resonance Images at 3.0T.

Author information

1
Departments of Radiology, University of California, San Diego, CA 92103, USA ; Department of Radiology and Advanced Imaging Research Center, University of Texas Southwestern Medical Center, 2201 Inwood Road, NE2.210B, Dallas, TX 75390-9085, USA.
2
Computational and Applied Statistics Laboratory, San Diego Supercomputer Center, University of California, San Diego, CA 92093, USA.
3
Departments of Radiology, University of California, San Diego, CA 92103, USA ; Departments of Medicine, University of California, San Diego, CA 92103, USA ; Department of Target Therapy Oncology, Kyoto University Graduate School of Medicine, Kyoto, Japan.
4
Departments of Pathology, University of California, San Diego, CA 92103, USA.
5
Department of Pathology, Penn State Hershey Medical Center, Hershey, PA 17033, USA.
6
Center for Liver Diseases, Inova Fairfax Hospital, Falls Church, VA 22042, USA.
7
Departments of Radiology, University of California, San Diego, CA 92103, USA.
8
Departments of Medicine, University of California, San Diego, CA 92103, USA.
9
Departments of Medicine, University of California, San Diego, CA 92103, USA ; VA San Diego Healthcare System, San Diego, CA 92161, USA.

Abstract

PURPOSE:

To noninvasively assess liver fibrosis using combined-contrast-enhanced (CCE) magnetic resonance imaging (MRI) and texture analysis.

MATERIALS AND METHODS:

In this IRB-approved, HIPAA-compliant prospective study, 46 adults with newly diagnosed HCV infection and recent liver biopsy underwent CCE liver MRI following intravenous administration of superparamagnetic iron oxides (ferumoxides) and gadolinium DTPA (gadopentetate dimeglumine). The image texture of the liver was quantified in regions-of-interest by calculating 165 texture features. Liver biopsy specimens were stained with Masson trichrome and assessed qualitatively (METAVIR fibrosis score) and quantitatively (% collagen stained area). Using L 1 regularization path algorithm, two texture-based multivariate linear models were constructed, one for quantitative and the other for quantitative histology prediction. The prediction performance of each model was assessed using receiver operating characteristics (ROC) and correlation analyses.

RESULTS:

The texture-based predicted fibrosis score significantly correlated with qualitative (r = 0.698, P < 0.001) and quantitative (r = 0.757, P < 0.001) histology. The prediction model for qualitative histology had 0.814-0.976 areas under the curve (AUC), 0.659-1.000 sensitivity, 0.778-0.930 specificity, and 0.674-0.935 accuracy, depending on the binary classification threshold. The prediction model for quantitative histology had 0.742-0.950 AUC, 0.688-1.000 sensitivity, 0.679-0.857 specificity, and 0.696-0.848 accuracy, depending on the binary classification threshold.

CONCLUSION:

CCE MRI and texture analysis may permit noninvasive assessment of liver fibrosis.

PMID:
26421287
PMCID:
PMC4569760
DOI:
10.1155/2015/387653
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for Hindawi Publishing Corporation Icon for PubMed Central
Loading ...
Support Center