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Biomed Res Int. 2015;2015:379071. doi: 10.1155/2015/379071. Epub 2015 Sep 1.

Biomarkers of Brain Damage: S100B and NSE Concentrations in Cerebrospinal Fluid--A Normative Study.

Author information

1
Laboratory for CSF and Neuroimmunology, Topelex Ltd., 190 00 Prague, Czech Republic ; Department of Neurology, The Military University Hospital Prague, 169 02 Prague, Czech Republic.
2
Laboratory for CSF and Neuroimmunology, Topelex Ltd., 190 00 Prague, Czech Republic.
3
Laboratory for CSF and Neuroimmunology, Topelex Ltd., 190 00 Prague, Czech Republic ; Department of Biology and Medical Genetics, Charles University 2nd Faculty of Medicine and University Hospital Motol, 150 06 Prague, Czech Republic.
4
Laboratory for CSF and Neuroimmunology, Topelex Ltd., 190 00 Prague, Czech Republic ; Department of Biochemistry and Microbiology, The Institute of Chemical Technology, 166 28 Prague, Czech Republic.

Abstract

NSE and S100B belong among the so-called structural proteins of the central nervous system (CNS). Lately, this group of structural proteins has been profusely used as specific biomarkers of CNS tissue damage. So far, the majority of the research papers have focused predominantly on the concentrations of these proteins in blood in relation to CNS damage of various origins. Considering the close anatomic and functional relationship between the brain or spinal cord and cerebrospinal fluid (CSF), in case of a CNS injury, a rapid and pronounced increase of the concentrations of structural proteins specifically in CSF takes place. This study inquires into the physiological concentrations of NSE and S100B proteins in CSF, carried out on a sufficiently large group of 601 patients. The detected values can be used for determination of a normal reference range in CSF in a clinical laboratory diagnostics.

PMID:
26421286
PMCID:
PMC4569754
DOI:
10.1155/2015/379071
[Indexed for MEDLINE]
Free PMC Article

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