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Dis Markers. 2015;2015:796052. doi: 10.1155/2015/796052. Epub 2015 Sep 1.

Syndecan-1 in Cancer: Implications for Cell Signaling, Differentiation, and Prognostication.

Author information

1
Division of Pathology, Department of Laboratory Medicine, Karolinska Institutet, Karolinska University Hospital, F-46, 141 86 Stockholm, Sweden.

Abstract

Syndecan-1, a cell surface heparan sulfate proteoglycan, is critically involved in the differentiation and prognosis of various tumors. In this review, we highlight the synthesis, cellular interactions, and the signalling pathways regulated by syndecan-1. The basal syndecan-1 level is also crucial for understanding the sequential changes involving malignant transformation, tumor progression, and advanced or disseminated cancer stages. Moreover, we focus on the cellular localization of this proteoglycan as cell membrane anchored and/or shed, soluble syndecan-1 with stromal or nuclear accumulation and how this may carry different, highly tissue specific prognostic information for individual tumor types.

PMID:
26420915
PMCID:
PMC4569789
DOI:
10.1155/2015/796052
[Indexed for MEDLINE]
Free PMC Article

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