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EMBO Rep. 2015 Nov;16(11):1413-4. doi: 10.15252/embr.201541309. Epub 2015 Sep 29.

A lncRNA to repair DNA.

Author information

1
NNF Center for Protein Research, University of Copenhagen, Copenhagen, Denmark.
2
IVBMB, University of Zurich, Zurich, Switzerland.

Abstract

Long non-coding RNAs (lncRNAs) have emerged as regulators of various biological processes, but to which extent lncRNAs play a role in genome integrity maintenance is not well understood. In this issue of EMBO Reports, Sharma et al [1] identify the DNA damage-induced lncRNA DDSR1 as an integral player of the DNA damage response (DDR). DDSR1 has both an early role by modulating repair pathway choices, and a later function when it regulates gene expression. Sharma et al [1] thus uncover a dual role for a hitherto uncharacterized lncRNA during the cellular response to DNA damage.

PMID:
26420434
PMCID:
PMC4641492
DOI:
10.15252/embr.201541309
[Indexed for MEDLINE]
Free PMC Article

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