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Nat Rev Mol Cell Biol. 2015 Nov;16(11):643-649. doi: 10.1038/nrm4067. Epub 2015 Sep 30.

Targeting Polycomb systems to regulate gene expression: modifications to a complex story.

Author information

1
Department of Biochemistry, South Parks Road, University of Oxford, OX1 3QU.
#
Contributed equally

Abstract

Polycomb group proteins are transcriptional repressors that are essential for normal gene regulation during development. Recent studies suggest that Polycomb repressive complexes (PRCs) recognize and are recruited to their genomic target sites through a range of different mechanisms, which involve transcription factors, CpG island elements and non-coding RNAs. Together with the realization that the interplay between PRC1 and PRC2 is more intricate than was previously appreciated, this has increased our understanding of the vertebrate Polycomb system at the molecular level.

PMID:
26420232
PMCID:
PMC5469428
DOI:
10.1038/nrm4067
[Indexed for MEDLINE]
Free PMC Article

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