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Nat Rev Mol Cell Biol. 2015 Nov;16(11):691-8. doi: 10.1038/nrm4068. Epub 2015 Sep 30.

The discovery of modular binding domains: building blocks of cell signalling.

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Raymond and Beverly Sackler Laboratory of Genetics and Molecular Medicine, the Richard D. Berlin Center for Cell Analysis and Modeling and the Department of Genetics and Genome Science, University of Connecticut School of Medicine, 263 Farmington Avenue, Farmington, Connecticut 06030-06403, USA.


Cell signalling - the ability of a cell to process information from the environment and change its behaviour in response - is a central property of life. Signalling depends on proteins that are assembled from a toolkit of modular domains, each of which confers a specific activity or function. The discovery of modular protein- and lipid-binding domains was a crucial turning point in understanding the logic and evolution of signalling mechanisms.

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