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Nat Cell Biol. 2015 Oct;17(10):1232-4. doi: 10.1038/ncb3245.

STIMATE reveals a STIM1 transitional state.

Author information

1
Fels Institute for Cancer Research and Molecular Biology, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.
2
Department of Medical Genetics &Molecular Biochemistry, Temple University School of Medicine, Philadelphia, Pennsylvania 19140, USA.

Abstract

Decreases in endoplasmic reticulum calcium content are sensed by resident STIM proteins, which can activate plasma membrane Orai channels to facilitate Ca(2+) entry. The role of STIMATE, a previously unknown component of the store-operated calcium entry complex, has now been identified and defined.

PMID:
26419802
PMCID:
PMC4608442
DOI:
10.1038/ncb3245
[Indexed for MEDLINE]
Free PMC Article

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