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Small. 2015 Nov 25;11(44):5907-11. doi: 10.1002/smll.201501835. Epub 2015 Sep 29.

Mesostructured TiO2 Gated Periodic Mesoporous Organosilica-Based Nanotablets for Multistimuli-responsive Drug Release.

Author information

1
State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun, Jilin, 130012, P. R. China.

Abstract

A multistimuli-responsive drug carrier is designed and successfully synthesized by self-assembly of thiol-modified periodic mesoporous organosilica (PMO) nanoparticles, coated gold nanoparticles (AuNPs), and mesostructured titanium dioxide (TiO2). Dye-loaded PMO-Au@TiO2 nanotablets are shown to respond to environmental changes (pH, temperature, and light) to achieve controlled release.

KEYWORDS:

drug delivery; mesoporous materials; organic-inorganic hybrid materials; self-assembly

PMID:
26418053
DOI:
10.1002/smll.201501835
[Indexed for MEDLINE]

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