Format

Send to

Choose Destination
Muscle Nerve. 2016 Jan;53(1):20-6. doi: 10.1002/mus.24921. Epub 2015 Nov 26.

Myasthenia gravis Lambert-Eaton overlap syndrome.

Author information

1
Department of Neurology, University of Alabama at Birmingham, Birmingham, Alabama.

Abstract

INTRODUCTION:

To assess whether a myasthenia gravis (MG) Lambert-Eaton overlap syndrome (MLOS) exists.

METHODS:

Case reports that met the universally accepted diagnostic criteria for MG and Lambert-Eaton myasthenic syndrome (LEMS) were sought through a PubMed search. Fifty-five possible cases of MLOS were identified.

RESULTS:

Thirty-nine cases met the diagnostic criteria for MG and LEMS. Analysis of clinical features showed that these patients have common MG and LEMS symptoms: oculo-bulbar paresis and good response to anti-cholinesterase for MG and limb weakness and decreased or absent reflexes for LEMS. All had the classical LEMS pattern in the repetitive nerve stimulation test: low compound muscle action potential amplitude and incremental response > 60% with brief exercise or at high rate of stimulation. Eight patients had combined positive acetylcholine receptor antibody (AChR-ab) or muscle-specific kinase-ab and voltage-gated calcium channel- ab tests.

CONCLUSIONS:

A myasthenia gravis Lambert-Eaton overlap syndrome (MLOS) does exist.

KEYWORDS:

LEMS; Lambert-Eaton myasthenic syndrome; MG; MLOS; myasthenia gravis; myasthenia gravis Lambert-Eaton overlap syndrome; myasthenic syndrome

PMID:
26418033
DOI:
10.1002/mus.24921
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center