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Nat Genet. 2015 Oct;47(10):1104-5. doi: 10.1038/ng.3407.

Adeno-associated virus finds its disease.

Author information

1
Departments of Medicine and Biochemistry, University of Washington, Seattle, Washington, USA.
2
Papé Family Pediatric Research Institute, Oregon Health and Science University, Portland, Oregon, USA.

Abstract

Adeno-associated virus (AAV) vectors have been widely adopted for use in gene therapy. A new study raises concerns regarding this approach, reporting that chromosomal insertions of AAV serotype 2 seem to activate proto-oncogenes in human hepatocellular carcinoma.

PMID:
26417859
PMCID:
PMC4762592
DOI:
10.1038/ng.3407
[Indexed for MEDLINE]
Free PMC Article

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