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Sci Rep. 2015 Sep 29;5:14634. doi: 10.1038/srep14634.

A 3D map of the islet routes throughout the healthy human pancreas.

Author information

1
National Institute of Diabetes, Nutrition and Metabolic Diseases "N.C. Paulescu", Bucharest, Romania.
2
National Institute of Pathology "Victor Babes", Romania.
3
Faculty of Engineering in Foreign Languages, Politehnica University of Bucharest, Romania.
4
Institute of Genetics, University of Bucharest, Bucharest, Romania.
5
University of Agronomic Sciences and Veterinary Medicine, Bucharest, Romania.
6
Clinical Institute of "Fundeni", Bucharest, Romania.

Abstract

Islets of Langerhans are fundamental in understanding diabetes. A healthy human pancreas from a donor has been used to asses various islet parameters and their three-dimensional distribution. Here we show that islets are spread gradually from the head up to the tail section of the pancreas in the form of contracted or dilated islet routes. We also report a particular anatomical structure, namely the cluster of islets. Our observations revealed a total of 11 islet clusters which comprise of small islets that surround large blood vessels. Additional observations in the peripancreatic adipose tissue have shown lymphoid-like nodes and blood vessels captured in a local inflammatory process. Our observations are based on regional slice maps of the pancreas, comprising of 5,423 islets. We also devised an index of sphericity which briefly indicates various islet shapes that are dominant throughout the pancreas.

PMID:
26417671
PMCID:
PMC4586491
DOI:
10.1038/srep14634
[Indexed for MEDLINE]
Free PMC Article

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