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J Lab Physicians. 2015 Jul-Dec;7(2):75-8. doi: 10.4103/0974-2727.163131.

Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus.

Author information

1
Department of Biochemistry, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, India.
2
Department of General Medicine, North East Indira Gandhi Institute of Health and Medical Science, Shillong, Meghalaya, India.

Abstract

BACKGROUND:

Insulin resistance (IR) is the key pathophysiological defect that leads to the development of type 2 diabetes mellitus. The purpose of this study was to estimate serum magnesium level and insulin sensitivity indices among type 2 diabetes mellitus patients and to see an association between them.

METHODS:

This study was carried out among 38 type 2 diabetic patients and forty age and sex matched controls. Serum fasting glucose, magnesium, insulin, urea, and creatinine levels were estimated. Insulin sensitivity indices, homeostasis model assessment for insulin resistance (HOMA-IR) and quantitative insulin sensitivity check index (QUICKI) levels were calculated as per formulae.

RESULTS:

A highly significant low serum magnesium level was found in diabetic subjects as compared to the controls. Statistically significant high HOMA levels (>2.6) and low QUICKI levels (<0.33) were found among the case group. An inverse, statistically significant correlation was found between serum magnesium and fasting insulin level. A highly statistically significant inverse correlation was found between serum magnesium and HOMA level, and a positive correlation was found between serum magnesium and QUICKI level, that is, serum magnesium level decreases with increase in IR. A strong association was also found between fasting serum insulin level and insulin sensitivity indices.

CONCLUSION:

This study showed a lower serum magnesium level in diabetic patients compared to control. A strong association was also found between serum magnesium level and insulin sensitivity indices. For proper management of type 2 diabetes, it may, therefore, be necessary to treat hypomagnesemia in these patients.

KEYWORDS:

Diabetes mellitus; homeostasis model assessment for insulin resistance; insulin resistance; magnesium; quantitative insulin sensitivity check index

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