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Philos Trans R Soc Lond B Biol Sci. 2015 Oct 19;370(1680):20140367. doi: 10.1098/rstb.2014.0367.

Present and future challenges of induced pluripotent stem cells.

Author information

1
Department Biology II, Ludwig Maximilians University Munich, 82152 Martinsried Planegg, Germany.
2
Center for iPS Cell Research and Application, Kyoto University, Kyoto 606-8507, Japan Gladstone Institute of Cardiovascular Disease, San Francisco, CA 94158, USA takahash@cira.kyoto-u.ac.jp.

Abstract

Growing old is our destiny. However, the mature differentiated cells making up our body can be rejuvenated to an embryo-like fate called pluripotency which is an ability to differentiate into all cell types by enforced expression of defined transcription factors. The discovery of this induced pluripotent stem cell (iPSC) technology has opened up unprecedented opportunities in regenerative medicine, disease modelling and drug discovery. In this review, we introduce the applications and future perspectives of human iPSCs and we also show how iPSC technology has evolved along the way.

KEYWORDS:

cancer; epigenetics; induced pluripotent stem cells; regenerative medicine; reprogramming

PMID:
26416678
PMCID:
PMC4633996
DOI:
10.1098/rstb.2014.0367
[Indexed for MEDLINE]
Free PMC Article

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