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Biochimie. 2015 Dec;119:1-5. doi: 10.1016/j.biochi.2015.09.028. Epub 2015 Sep 28.

Eighty percent of French sport winners in Olympic, World and Europeans competitions have mutations in the hemochromatosis HFE gene.

Author information

1
IRMES - Institute for Research in BioMedecine and Epidemiology of Sport, Paris, France; CNRS UMR 8147, Necker Hospital, AP-HP, Paris, France; Institute of Genetic Diseases, Foundation Imagine, Paris, France; GR-Ex, Paris Descartes University, Sorbonne Paris Cité, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France. Electronic address: ohermine@gmail.com.
2
IRMES - Institute for Research in BioMedecine and Epidemiology of Sport, Paris, France; Biomodeling Systems, Ecole Centrale, Paris, France; Biotechnology Insitute of Troyes, IBT, Troyes, France.
3
Biotechnology Insitute of Troyes, IBT, Troyes, France; Amarok Biotechnologies, Saint Malo, France.
4
IRMES - Institute for Research in BioMedecine and Epidemiology of Sport, Paris, France; National Institute of Sport, Expertise and Performance - INSEP, Paris, France.
5
Biotechnology Insitute of Troyes, IBT, Troyes, France.
6
IRMES - Institute for Research in BioMedecine and Epidemiology of Sport, Paris, France; GR-Ex, Paris Descartes University, Sorbonne Paris Cité, Paris, France; INSERM, U970, Paris Cardiovascular Research Center - PARCC, Paris, France; National Institute of Sport, Expertise and Performance - INSEP, Paris, France.
7
CNRS UMR 8147, Necker Hospital, AP-HP, Paris, France; Institute of Genetic Diseases, Foundation Imagine, Paris, France; GR-Ex, Paris Descartes University, Sorbonne Paris Cité, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France.
8
Skiing French Federation, Annecy, France.
9
Rowing French Federation, Nogent-sur-Marne, France; National Institute of Sport, Expertise and Performance - INSEP, Paris, France.
10
National Institute of Sport, Expertise and Performance - INSEP, Paris, France; Archery French Federation, Paris, Paris, France.
11
Petanque French Federation, Marseille, France.
12
National Institute of Sport, Expertise and Performance - INSEP, Paris, France; Judo French Federation, Paris, France.
13
GR-Ex, Paris Descartes University, Sorbonne Paris Cité, Paris, France; INSERM, U970, Paris Cardiovascular Research Center - PARCC, Paris, France.
14
IRMES - Institute for Research in BioMedecine and Epidemiology of Sport, Paris, France; GR-Ex, Paris Descartes University, Sorbonne Paris Cité, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France; National Institute of Sport, Expertise and Performance - INSEP, Paris, France.
15
IRMES - Institute for Research in BioMedecine and Epidemiology of Sport, Paris, France; GR-Ex, Paris Descartes University, Sorbonne Paris Cité, Paris, France; Paris Descartes University, Sorbonne Paris Cité, Paris, France; National Institute of Sport, Expertise and Performance - INSEP, Paris, France; Investigation Center in Sport Medecine - CIMS, Hôtel-Dieu, AP-HP, Paris, France. Electronic address: jean-francois.toussaint@htd.aphp.fr.

Abstract

The HFE gene encodes a protein involved in iron homeostasis; individuals with mutations in both alleles develop hemochromatosis. 27% of the French population is heterozygous for mutations in this gene. We found that 80% of the French athletes who won international competitions in rowing, Nordic skiing and judo display mutations in one allele of HFE, thus demonstrating the existence of a favourable phenotype linked to this heterozygosity.

KEYWORDS:

Athlete; Gene; HFE mutation frequency; Iron

PMID:
26416567
DOI:
10.1016/j.biochi.2015.09.028
[Indexed for MEDLINE]

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