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Nat Rev Neurol. 2016 Jan;12(1):56-61. doi: 10.1038/nrneurol.2015.177. Epub 2015 Sep 29.

CAP--advancing the evaluation of preclinical Alzheimer disease treatments.

Author information

1
Banner Alzheimer's Institute, 901 E. Willetta Street, Phoenix, AZ 85006, USA.
2
Grupo de Neurosciencias, Universidad de Antioquia, Calle 62 #52-59, Medellin, Colombia.
3
Department of Neurology, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA.
4
Department of Neurology, Brigham and Women's Hospital, 221 Longwood Avenue, Boston, MA 02115, USA.
5
University of Southern California Alzheimer's Therapeutic Research Institute, 10182 Telesis Court, San Diego, CA 92121, USA.
6
Joseph and Kathleen Bryan Alzheimer's Disease Research Center, Department of Neurology, Duke University Medical Center, 2200 West Main Street, Durham, NC 27705, USA.
7
Alzheimer's Association, Medical &Scientific Relations Division, 225 North Michigan Avenue, Chicago, IL 60601, USA.
8
Fidelity Biosciences Research Initiative, One Main Street, Cambridge, MA 02142, USA.

Abstract

If we are to find treatments to postpone, reduce the risk of, or completely prevent the clinical onset of Alzheimer disease (AD), we need faster methods to evaluate promising preclinical AD treatments, new ways to work together in support of common goals, and a determination to expedite the initiation and performance of preclinical AD trials. In this article, we note some of the current challenges, opportunities and emerging strategies in preclinical AD treatment. We describe the Collaboration for Alzheimer's Prevention (CAP)-a convening, harmonizing and consensus-building initiative to help stakeholders advance AD prevention research with rigour, care and maximal impact-and we demonstrate the impact of CAP on the goals and design of new preclinical AD trials.

PMID:
26416539
PMCID:
PMC4847536
DOI:
10.1038/nrneurol.2015.177
[Indexed for MEDLINE]
Free PMC Article

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