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Diagn Microbiol Infect Dis. 2015 Dec;83(4):379-81. doi: 10.1016/j.diagmicrobio.2015.08.013. Epub 2015 Aug 28.

Differences in potency and categorical agreement between colistin and polymyxin B when testing 15,377 clinical strains collected worldwide.

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JMI Laboratories, North Liberty, IA, USA. Electronic address:
JMI Laboratories, North Liberty, IA, USA.


Gram-negative bacilli (n=15,377) were tested against colistin (polymyxin E) and polymyxin B by a commercial broth microdilution method (Sensititre®). Among Pseudomonas aeruginosa and Acinetobacter spp., colistin and polymyxin B MIC values were within ±1 doubling dilution for >99.0% of strains. Among Klebsiella spp. and Escherichia coli, 55.0 and 53.2% of strains displayed a colistin MIC 2-fold lower than polymyxin B, but polymyxin B was slightly more potent than colistin against strains with decreased susceptibility to either polymyxin.


Broth microdilution method; Polymyxins; Susceptibility testing

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