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Sci Rep. 2015 Sep 29;5:14224. doi: 10.1038/srep14224.

Increased epigenetic alterations at the promoters of transcriptional regulators following inadequate maternal gestational weight gain.

Author information

1
Department of Maternal-Fetal Biology, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
2
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan.
3
Department of Systems BioMedicine, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.
4
Division of Developmental Genomics, National Research Institute for Child Health and Development, Tokyo 157-8535, Japan.

Abstract

Epigenetic modifications are thought to serve as a memory of exposure to in utero environments. However, few human studies have investigated the associations between maternal nutritional conditions during pregnancy and epigenetic alterations in offspring. In this study, we report genome-wide methylation profiles for 33 postpartum placentas from pregnancies of normal and foetal growth restriction with various extents of maternal gestational weight gain. Epigenetic alterations accumulate in the placenta under adverse in utero environments, as shown by application of Smirnov-Grubbs' outlier test. Moreover, hypermethylation occurs frequently at the promoter regions of transcriptional regulator genes, including polycomb targets and zinc-finger genes, as shown by annotations of the genomic and functional features of loci with altered DNA methylation. Aberrant epigenetic modifications at such developmental regulator loci, if occurring in foetuses as well, will elevate the risk of developing various diseases, including metabolic and mental disorders, later in life.

PMID:
26415774
PMCID:
PMC4586460
DOI:
10.1038/srep14224
[Indexed for MEDLINE]
Free PMC Article
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