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Nat Neurosci. 2015 Nov;18(11):1565-7. doi: 10.1038/nn.4125. Epub 2015 Sep 28.

A positive-negative mode of population covariation links brain connectivity, demographics and behavior.

Author information

1
Oxford University Centre for Functional MRI of the Brain (FMRIB), Oxford, UK.
2
Department of Statistics and Warwick Manufacturing Group, University of Warwick, Coventry, UK.
3
Oxford University Centre for Human Brain Activity (OHBA), Oxford, UK.
4
Washington University School of Medicine, Washington University, St. Louis, Missouri, USA.
5
Center for Magnetic Resonance Research, University of Minnesota, Minnesota, USA.

Abstract

We investigated the relationship between individual subjects' functional connectomes and 280 behavioral and demographic measures in a single holistic multivariate analysis relating imaging to non-imaging data from 461 subjects in the Human Connectome Project. We identified one strong mode of population co-variation: subjects were predominantly spread along a single 'positive-negative' axis linking lifestyle, demographic and psychometric measures to each other and to a specific pattern of brain connectivity.

PMID:
26414616
PMCID:
PMC4625579
DOI:
10.1038/nn.4125
[Indexed for MEDLINE]
Free PMC Article

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