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Curr Biol. 2015 Oct 19;25(20):2610-20. doi: 10.1016/j.cub.2015.08.042. Epub 2015 Sep 24.

A Hardwired Circuit Supplemented with Endocannabinoids Encodes Behavioral Choice in Zebrafish.

Author information

1
Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden.
2
Department of Neuroscience, Karolinska Institute, 171 77 Stockholm, Sweden. Electronic address: abdel.elmanira@ki.se.

Erratum in

  • Curr Biol. 2016 Jan 11;26(1):137.

Abstract

Animals constantly make behavioral choices to facilitate moving efficiently through their environment. When faced with a threat, animals make decisions in the midst of other ongoing behaviors through a context-dependent integration of sensory stimuli. In vertebrates, the mechanisms underlying behavioral selection are poorly understood. Here, we show that ongoing swimming in zebrafish is suppressed by escape. The selection of escape over swimming is mediated by switching between two distinct motoneuron pools. A hardwired circuit mediates this switch by acting as a clutch-like mechanism to disengage the swimming motoneuron pool and engage the escape motoneuron pool. Threshold for escape initiation is lowered and swimming suppression is prolonged by endocannabinoid neuromodulation. Thus, our results reveal a novel cellular mechanism involving a hardwired circuit supplemented with endocannabinoids acting as a clutch-like mechanism to engage/disengage distinct motor pools to ensure behavioral selection and a smooth execution of motor action sequences in a vertebrate system.

PMID:
26412127
DOI:
10.1016/j.cub.2015.08.042
[Indexed for MEDLINE]
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