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Curr Neuropharmacol. 2015;13(4):524-35.

The Antidepressant-like Effects of Estrogen-mediated Ghrelin.

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1
Life Sciences institute, Northeast Normal University, Changchun, China 130024.

Abstract

Ghrelin, one of the brain-gut peptides, stimulates food-intake. Recently, ghrelin has also shown to play an important role in depression treatment. However, the mechanism of ghrelin's antidepressant-like actions is unknown. On the other hand, sex differences in depression, and the fluctuation of estrogens secretion have been proved to play a key role in depression. It has been reported that women have higher level of ghrelin expression, and ghrelin can stimulate estrogen secretion while estrogen acts as a positive feedback mechanism to up-regulate ghrelin level. Ghrelin may be a potential regulator of reproductive function, and estrogen may have additional effect in ghrelin's antidepressantlike actions. In this review, we summarize antidepressant-like effects of ghrelin and estrogen in basic and clinical studies, and provide new insight on ghrelin's effect in depression.

PMID:
26412072
PMCID:
PMC4790402
[Indexed for MEDLINE]
Free PMC Article

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