[Genetic Association of ADRA2A and ADRB3 Genes with Metabolic Syndrome among the Tatars]

Genetika. 2015 Jul;51(7):830-4.
[Article in Russian]

Abstract

An association study was performed for genetic polymorphisms in ADRB3 (rs4994) and ADRA2A (rs1800544, rs553668) genes to estimate their effect on quantitative parameters, including glucose, insulin, and HOMA-IR index in women from the Tatar population of Russia. It has been shown that CT and CC are associated with metabolic syndrome and increased insulin. It was shown that ADRA2A (rs1800544) gene polymorphism was associated with high levels of insulin and an increased HOMA-IR index in GG- and GC-genotype carriers.

MeSH terms

  • Blood Glucose / genetics
  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / genetics
  • Female
  • Genetic Predisposition to Disease
  • Heterozygote
  • Humans
  • Insulin / blood
  • Insulin / genetics
  • Metabolic Syndrome / genetics*
  • Polymorphism, Single Nucleotide*
  • Receptors, Adrenergic, alpha-2 / genetics*
  • Receptors, Adrenergic, beta-3 / genetics*
  • Russia / ethnology

Substances

  • ADRA2A protein, human
  • ADRB3 protein, human
  • Blood Glucose
  • Insulin
  • Receptors, Adrenergic, alpha-2
  • Receptors, Adrenergic, beta-3