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Surg Obes Relat Dis. 2016 Jan;12(1):11-20. doi: 10.1016/j.soard.2015.04.011. Epub 2015 Apr 23.

Long-term outcomes after Roux-en-Y gastric bypass: 10- to 13-year data.

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Department of Surgery, New York University School of Medicine, New York, New York. Electronic address:
Department of Surgery, New York University School of Medicine, New York, New York.
Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania.



Short- and mid-term data on Roux-en-Y gastric bypass (RYGB) indicate sustained weight loss and improvement in co-morbidities. Few long-term studies exist, some of which are outdated, based on open procedures or different techniques.


To investigate long-term weight loss, co-morbidity remission, nutritional status, and complication rates among patients undergoing RYGB.


An academic, university hospital in the United States.


Between October 2000 and January 2004, patients who underwent RYGB≥10 years before study onset were eligible for chart review, office visits, and telephone interviews. Revisional surgery was an endpoint, ceasing eligibility for study follow-up. Outcomes included weight loss measures and rates of co-morbidity remission, complications, and nutritional deficiencies.


RYGB was performed in 328 patients with a mean preoperative body mass index of 47.5 kg/m(2). Of 294 eligible patients, 134 (46%) were contacted for follow-up at ≥ 10 years (10+Year follow-up). Mean percentage excess weight loss (%EWL) was 58.9% at 10+Year. Higher %EWL was achieved by non-super-obese versus super-obese (61.3% versus 52.9%, P = .034). Blood pressure, lipid panel, and hemoglobin A1c improved significantly. At 10 years, remission of co-morbidities was 46% for hypertension and hyperlipidemia and 58% for diabetes mellitus. Thirty patients (9%) had revisional surgery for weight regain. Sixty-four patients (19.5%) had long-term complications requiring surgery. All-cause mortality was 2.7%. Nutritional deficiencies were seen in 87% of patients.


Weight loss after RYGB appears to be significant and sustainable, especially in the non-super-obese. Co-morbidities are improved, with a substantial number in remission a decade later. Nutritional deficiencies are almost universal.


Co-morbidity; Complications; Gastric bypass; Long-term; Nutrition; Weight loss

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