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J Am Acad Dermatol. 2015 Dec;73(6):998-1005. doi: 10.1016/j.jaad.2015.08.052. Epub 2015 Sep 26.

Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS).

Author information

1
Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany.
2
Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, Bochum, Germany. Electronic address: f.bechara@klinikum-bochum.de.

Abstract

BACKGROUND:

Data regarding the association of routinely obtained serum markers of inflammation, namely C-reactive protein (CRP), white blood cell count, and neutrophil count, with disease severity of hidradenitis suppurativa (HS) according to a scoring system have not been reported to our knowledge.

OBJECTIVE:

We sought to evaluate these inflammatory serum markers for assessing disease severity of HS.

METHODS:

Medical files of 275 patients who were referred to the outpatient HS center of the Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, in 2013 were evaluated retrospectively.

RESULTS:

CRP levels and neutrophil count significantly differed among Hurley stages I, II and III (P < .0001, P = .0002, respectively). There were significant positive correlations among CRP levels (r = 0.496, P < .0001) and neutrophil count (r = 0.330, P = .0009) with modified Hidradenitis Suppurativa Score. CRP was a significant independent predictor for Hurley stage III (odds ratio 1.077, 95% confidence interval 1.013-1.145, P = .016). CRP and body mass index were significant independent predictors for severe disease according to modified Hidradenitis Suppurativa Score (odds ratio 1.065, 95% confidence interval 1.015-1.117, P = .009; and odds ratio 1.12, 95% confidence interval 1.009-1.243, P = .032, respectively).

LIMITATIONS:

Files were analyzed retrospectively.

CONCLUSION:

These inflammatory markers, especially CRP, are effective for assessing the extent of disease severity and the grade of inflammation in patients with HS.

KEYWORDS:

C-reactive protein; biomarkers; hidradenitis suppurativa; inflammation; inflammatory skin disease; serum markers for inflammation

PMID:
26410359
DOI:
10.1016/j.jaad.2015.08.052
[Indexed for MEDLINE]

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