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Crit Care Clin. 2015 Oct;31(4):751-62. doi: 10.1016/j.ccc.2015.06.010. Epub 2015 Jul 29.

Short-term Effects of Acute Kidney Injury.

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Department of Anesthesiology, Penn State College of Medicine, Milton S. Hershey Medical Center, P.O. Box 850, H187 Hershey, PA 17033, USA.
Division of Intensive Care and Emergency Medicine, Department of Internal Medicine, Medical University Innsbruck, Anichstr. 35, Innsbruck A-6020, Austria. Electronic address:


Acute kidney injury (AKI) is associated with significant short-term morbidity and mortality, which cannot solely be explained by loss of organ function. Renal replacement therapy allows rapid correction of most acute changes associated with AKI, indicating that additional pathogenetic factors play a major role in AKI. Evidence suggests that reduced renal cytokine clearance as well as increased cytokine production by the acutely injured kidney contribute to a systemic inflammation state, which results in significant effects on other organs. AKI seems to compromise the function of the innate immune system. AKI is an acute systemic disease with serious distant organ effects.


Acute kidney injury; Cytokines; Electrolytes; Immune system; Inflammatory mediators; Neutrophils; Short term; Uremic toxins

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