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Clin Infect Dis. 2015 Oct 15;61Suppl 3:S225-34. doi: 10.1093/cid/civ614.

B in TB: B Cells as Mediators of Clinically Relevant Immune Responses in Tuberculosis.

Author information

1
Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet.
2
Division of Therapeutic Immunology, Department of Laboratory Medicine, Karolinska Institutet Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital Huddinge, Stockholm, Sweden.
3
Division of Infection and Immunity, University College London, and NIHR Biomedical Research Centre at University College Hospitals NHS Foundation Trust, United Kingdom.
4
Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Stockholm, Sweden.

Abstract

The protective role of B cells and humoral immune responses in tuberculosis infection has been regarded as inferior to cellular immunity directed to the intracellular pathogen Mycobacterium tuberculosis. However, B-cell-mediated immune responses in tuberculosis have recently been revisited in the context of B-cell physiology and antigen presentation. We discuss in this review the diverse functions of B cells in tuberculosis, with a focus on their biological and clinical relevance to progression of active disease. We also present the peptide microarray platform as a promising strategy to discover unknown antigenic targets of M. tuberculosis that could contribute to the better understanding of epitope focus of the humoral immune system against M. tuberculosis.

KEYWORDS:

B cells; antibodies; cytokines; host-directed therapy; tuberculosis

PMID:
26409285
PMCID:
PMC4583574
DOI:
10.1093/cid/civ614
[Indexed for MEDLINE]
Free PMC Article

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