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Clin Infect Dis. 2015 Oct 15;61Suppl 3:S155-9. doi: 10.1093/cid/civ611.

RePORT International: Advancing Tuberculosis Biomarker Research Through Global Collaboration.

Author information

1
Scientific Affairs, Global Health, Population and Nutrition, FHI 360 Department of Medicine, Division of Infectious Diseases, Duke University School of Medicine, Durham, North Carolina.
2
Department of Clinical Research, National Institute for Research in Tuberculosis, Chennai and Pune.
3
Pulmonary Medicine, Christian Medical College, Vellore, India.
4
School of Medicine, Boston University, Massachusetts.
5
School of Medicine, Johns Hopkins University, Baltimore, Maryland.
6
Department of Medicine, Division of Infectious Diseases, Vanderbilt University School of Medicine, Nashville, Tennessee.
7
National Institute of Infectious Diseases Evandro Chagas-Fiocruz, Rio de Janeiro, Brazil.
8
Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
9
Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health The National Institute of Research and Development, Indonesia Ministry of Health, Jakarta, Indonesia.
10
Collaborative Clinical Research Branch, Division of Clinical Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health.
11
Health Studies Sector, Westat, Rockville, Maryland.

Abstract

Progress in tuberculosis clinical research is hampered by a lack of reliable biomarkers that predict progression from latent to active tuberculosis, and subsequent cure, relapse, or failure. Regional Prospective Observational Research in Tuberculosis (RePORT) International represents a consortium of regional cohorts (RePORT India, RePORT Brazil, and RePORT Indonesia) that are linked through the implementation of a Common Protocol for data and specimen collection, and are poised to address this critical research need. Each RePORT network is designed to support local, in-country tuberculosis-specific data and specimen biorepositories, and associated research. Taken together, the expected results include greater global clinical research capacity in high-burden settings, and increased local access to quality data and specimens for members of each network and their domestic and international collaborators. Additional networks are expected to be added, helping to spur tuberculosis treatment and prevention research around the world.

KEYWORDS:

biological markers; biological specimen banks; prospective studies; specimen handling; tuberculosis

PMID:
26409277
PMCID:
PMC4583572
DOI:
10.1093/cid/civ611
[Indexed for MEDLINE]
Free PMC Article

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